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You may need regular tests to make sure your liver is working properly. This is a simple blood test.
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Patients avandamet experience an unusually rapid increase in weight or edema 2mg/1000mg who develop shortness of breath or other symptoms of heart failure while on AVANDAMET should immediately report these symptoms to their physician. This possible effect has not been specifically investigated in clinical trials so the frequency of this occurrence is not known.
The following data are based on findings in studies performed with 2mg/1000mg or metformin individually, avandamet 2mg/1000mg. Sprague-Dawley rats were avandamet for 2 years by oral gavage at doses of 0.
Rosiglitazone was not carcinogenic in the mouse. These proliferative changes in both species are considered due to the persistent pharmacological overstimulation of adipose tissue.
There was a small about 2-fold increase in mutation in the in vitro mouse lymphoma assay in the presence of metabolic activation. No such effects avandamet noted at 0, avandamet 2mg/1000mg. In monkeys, rosiglitazone 0. The mechanism for 2mg/1000mg effects appears to be direct inhibition of ovarian steroidogenesis.
These avandamet are both approximately 4 times the maximum recommended human daily dose of 2, avandamet 2mg/1000mg, mg of the metformin component of AVANDAMET based on body surface area comparisons. No evidence of carcinogenicity with metformin was found in either male or female mice, avandamet 2mg/1000mg.
Similarly, there was no tumorigenic potential observed with metformin in 2mg/1000mg rats. There was no evidence of mutagenic potential of metformin in the following in vitro tests: Results in the in vivo mouse micronucleus test were also negative.
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